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Literature summary extracted from

  • Karsten, W.E.; Cook, P.F.
    Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase (2002), Methods Enzymol., 354, 223-237.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.45 L-serine + glyoxylate Hyphomicrobium methylovorum part of the C-1 assimilation pathway 3-hydroxypyruvate + glycine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.45 Hyphomicrobium methylovorum
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.45 L-serine + glyoxylate = 3-hydroxypyruvate + glycine ping-pong reaction mechanism Hyphomicrobium methylovorum
a
2.6.1.45 L-serine + glyoxylate = 3-hydroxypyruvate + glycine reaction is catalyzed via the initial formation of an external Schiff base intermediate Hyphomicrobium methylovorum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.45 L-serine + glyoxylate part of the C-1 assimilation pathway Hyphomicrobium methylovorum 3-hydroxypyruvate + glycine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.45 pyridoxal 5'-phosphate
-
 Hyphomicrobium methylovorum